24-homo vitamin D derivatives, process for their production and pharmaceutical preparations obtained therefrom

US5665716A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Gerald Kirsch · Berlin, DE
• Gunter Neef · Berlin, DE
• Katicia Schwarz · Berlin, DE
• Matthias Brautigam · Berlin, DE
• Ruth Thieroff-Ekerdt · Concord, US
• Petra Rach · Berlin, DE

Key dates

• Filing date: Oct 2, 1990
• Grant date: Sep 9, 1997
• Expiry date: Oct 2, 2010

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

New 24-homo vitamin D derivatives of formula I ##STR1## are described, in which R.sup.1 means a hydrogen atom, a hydroxy, an alkanoyloxy group with 1 to 8 carbon atoms or an aralkanoyloxy group with up to 8 carbon atoms, PA1 R.sup.2 and R.sup.3, independently of one another, mean a linear or branched alkyl group with 1 to 4 carbon atoms, a trifluoromethyl group or together mean a saturated carbocyclic ring with 3 to 9 carbon atoms formed with carbon atom 25, PA1 R.sup.4 and R.sup.5, independently of one another, mean a hydrogen atom, an alkanoyl group with 1 to 8 carbon atoms or an aralkanoyl group with up to 8 carbon atoms, and PA1 A and B each mean a hydrogen or together a second bond, and PA1 n stands for 1, 2, 3,4 or 5.