Human cancer inhibitory peptide amides
US5665860A · kind A · utility
68Cited by
3References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 13, 1996 |
| Grant date | Sep 9, 1997 |
| Priority date | — |
| Expiry date | Jun 13, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This application discloses seven newly synthesized pentapeptide amides and our tetrapeptide amides. The synthesis utilized both naturally occurring and modified amino acids; the modified amino acids are constituents of the well known dolastatin 10 and dolastatin 15 which are structurally distinct peptides with excellent antineoplastic activity. These peptides were constructed by introducing a peptide bond between selected amino acids and modified amino acids and coupling the resulting di- and tri-peptides to obtain peptides having a high anticancer activity against a series of human cancer cell lines. ##STR1##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.