Method and composition for prevention and treatment of female lower genital tract microbial infections
US5667817A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Aug 28, 1996 |
| Grant date | Sep 16, 1997 |
| Priority date | — |
| Expiry date | Aug 28, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K33/40
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for preventing and treating microbial infections in the mammalian female lower genital tract such as vulvitis, vaginitis, cervicitis, and endometritis involve the intra-vaginal and/or intra-uterine infusion of a solution containing a pharmacologically acceptable carrier and chlorine dioxide in an amount ranging from about 5 ppm to 1000 ppm, and having a chlorine dioxide to chlorite ratio of at least 5:1. Typical solutions exhibit a pH compatible with the lower genital tract, e.g., a pH from about 5 to about 7.5. In many embodiments, chlorine dioxide in the solution is produced by reacting a chlorite with a mineral acid and adjusting the pH, by reacting a chlorite with an organic acid having a pK of about 2.8 to 4.2, or by reacting a chlorite at a pH below about 5.5 with a heat-activated saccharide in the presence of an organic acid having a pK of about 2.8 to about 4.2. Sodium chlorite is employed in preferred embodiments.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.