Dihydropyridine NPY antagonists: piperidine derivatives

US5668151A · kind A · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Graham S. Poindexter · Old Saybrook, US
• Marc Bruce · Wallingford, US
• Graham Johnson · Madison, US
• Karen LeBoulluec · Wallingford, US
• Charles P. Sloan · Wallingford, US

Key dates

• Filing date: May 8, 1996
• Grant date: Sep 16, 1997
• Expiry date: May 8, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D211/90
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of piperidine and tetrahydropyridine derivatives of 4-phenyl-1,4-dihydropyridines of Formula I. ##STR1## As antagonists of NPY-induced feeding behavior, these compounds are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.