1,2-dithiin antiinfective agents

US5668168A · kind A · utility

Assignees

• Shaman Pharmaceuticals, Inc. · US
• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Thien V. Truong · Emeryville, US
• Donald Bierer · Daly City, US
• Jeffrey Mark Dener · Menlo Park, US
• Richard F. Hector · Dublin, US
• Michael S. Tempesta · Moss Beach, US
• Bernard Loev · Scarsdale, US
• Wu Yang · Ann Arbor, US
• Masato Koreeda · Ann Arbor, US

Key dates

• Filing date: Jun 6, 1995
• Grant date: Sep 16, 1997
• Expiry date: Jun 6, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D339/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention pertains to a novel group of 1,2-dithiin compounds useful as antiinfective agents, and a novel synthetic process to produce the same. The compounds are particularly effective in treating fungal infections, especially those caused by Candida albicans, Cryptococcus neoformans or Aspergillus fumigatus.