Certain aryl substituted pyrrolopyrazines; a new class of GABA brain receptor ligands
US5668283A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 7, 1995 |
| Grant date | Sep 16, 1997 |
| Priority date | — |
| Expiry date | Jun 7, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention encompasses compounds of the formula: ##STR1## and pharmaceutically acceptable non-toxic salts thereof wherein: ##STR2## represents: ##STR3## where n is 0, 1, or 2; R.sub.1 and R.sub.2 are hydrogen or straight or branched chain alkyl groups; PA1 Y represents various organic and inorganic substituents; PA1 W represents an aromatic group substituted with various organic and inorganic substituents; PA1 A is CH or N; PA1 B is a substituted or unsubstituted carbon or N; and PA1 E is hydrogen or straight or branched alkyl groups These compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs thereof and are useful in the diagnosis and treatment of anxiety, sleep, and seizure disorders, overdose with benzodiazepine type drugs, and enhancement of alertness.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.