Preservatives and their use

US5670160A · kind A · utility

Assignee

• Schulke & Mayr GmbH · DE

Inventors

• Heinz Eggensperger · Hamburg, DE
• Karl-Heinz Diehl · Norderstedt, DE
• Peter Oltmanns · Hamburg, DE

Key dates

• Filing date: Jan 30, 1996
• Grant date: Sep 23, 1997
• Expiry date: Jan 30, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2800/524
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A preservative, for compositions having an aqueous phase, comprising PA1 a) 5 to 60% by weight of an organic acid selected from the group consisting of benzoic acid, 4-hydroxybenzoic acid, salicylic acid, formic acid, acetic acid, propionic acid, sorbic acid, undecylenic acid and dehydracetic acid or their mixtures including their sodium, potassium, calcium, magnesium, ammonium and ethanolamine salts PA1 b) 10 to 95% by weight of alcohols of the general formulae I, II or III ##STR1## in which R.sub.1 denotes hydrogen, an n-alkyl, iso-alkyl or alkoxy radical having 1 to 3 C atoms, and R.sub.2 and R.sub.3 denote hydrogen or a CH.sub.3 -- or C.sub.2 H.sub.5 -- radical and n has the value of 3 or 4, and PA1 c) 0.1 to 20% by weight of one or more poly(hexa-methylenebiguanide) salts of the general formula ##STR2## in which Z represents hydrochloride, acetate, lactate, benzoate, propionate, 4-hydroxybenzoate, sorbate or salicylate; and n has the value of 4 to 6, in combination in a customary carrier or solvent.