Anti-tumor agent assay using PKR
US5670330A · kind A · utility
12Cited by
1References
9Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Oct 25, 1993 |
| Grant date | Sep 23, 1997 |
| Priority date | — |
| Expiry date | Oct 25, 2013 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/5011
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method of screening human tissue for the presence of neoplastic cells, by determining the activity of PKR, P58 of anti-P58 in test cells being screened, and identifying candidate neoplastic cells on the basis of subnormal PKR, P58, or anti-P58 activity. The activities may be determined directly by measuring protein kinase activity or its equivalent, or measured indirectly, by detecting functional mutations in the various proteins. Also disclosed are assay kits for carrying out the screening method.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.