Patent · US Expired

Stable growth transformation of human T-lymphocytes by Herpesvirus saimiri (H. saimiri) subgroup C

US5670352A · kind A · utility

2Cited by

1References

23Claims

0Family size

Assignee

Behringwerke Aktiengesellschaft · DE

Inventors

Brigitte Biesinger-Zwosta · Uttenreuth, DE
Ingrid Mueller-Fleckenstein · Wiesenthau, DE
Bernhard Fleckenstein · Wiesenthau, DE

Key dates

Filing date	Apr 27, 1995
Grant date	Sep 23, 1997
Priority date	—
Expiry date	Apr 27, 2015

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N15/65
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The invention concerns the transformation of human T-lymphocytes to stable growth by infecting said T-cells with strains of H. saimiri subgroup NonA NonB, preferably subgroup C. The transformed cells grow independently of antigen stimulation and can have a phenotype of activated mature T-lymphocytes, expressing cell surface markers characteristic for the distinct differentiation status of the T-cells. Infection with strains of H. saimiri belonging to the subgroups above can thus be used to generate human T-cell lines for a variety of immunological and biochemical applications as well as for therapeutic use.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.