Protein polyligands joined to a stable protein core
US5672486A · kind A · utility
28Cited by
1References
8Claims
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Key dates
| Filing date | Aug 20, 1992 |
| Grant date | Sep 30, 1997 |
| Priority date | — |
| Expiry date | Aug 20, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/75
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Stable polyligands are provided by preparing fused proteins, where the fused protein comprises a ligand at one terminus and a subunit of a multimeric unit protein at the other terminus, where the fused protein is able to assemble to provide a polyligand. The polyligands find use in modulating physiological processes by inhibiting ligand induced signal transduction by surface membrane protein receptors and/or in the case of .mu. chain use, by complement mediated killing or any other effector functions. The molecule may be composed solely, of human components to avoid an immune response by the recipient.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.