3-8-diazabicyclo 3.2.1! octane derivatives having analgesic activity
US5672601A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Aug 22, 1996 |
| Grant date | Sep 30, 1997 |
| Priority date | — |
| Expiry date | Aug 22, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of general formula (I) ##STR1## wherein R and R.sub.1, different from each other, are a straight or branched C.sub.2 -C.sub.8 acyl group; a group of formula --CH.sub.2 -- (A)--B wherein: A is a single bond between two carbon atoms, or a group of formula --CH--CH, --CH.sub.2 --CO--, B is a C.sub.6 -C.sub.10 aryl group, optionally substituted, at the ortho-meta- and para-positions, with one or more substituents, which are the same or different, selected from the group consisting of CONHR, carboxyl, cyano, nitro, NHCOR; an aromatic heterocyclic or alicyclic group with 5 or 6 members in the ring, optionally benzocondensed, having at least one heteroatom selected from nitrogen, oxygen, sulfur, said heterocyclic group optionally having one or more substituents as described above for the aryl group; with the proviso that when one of R or R.sub.1 is the propionyl group, the other can not be the cinnamyl group or the p-nitrocinnamyl group, and when R is the propionyl group, R.sub.1 cannot be o-, or m-nitrocinnamyl; and the pharmaceutically acceptable salts thereof. Compounds of formula (I) have central analgesic activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.