Protein kinase C inhibitors

US5672618A · kind A · utility

Assignee

• ELI LILLY AND COMPANY · US

Inventors

• William F. Heath, Jr. · Fishers, US
• John H. McDonald, III · Carmel, US
• Michael Paal · Hamburg, DE
• Theo Schotten · Winsen (Luhe), DE
• Wolfgang Stenzel · Reinbek, DE

Key dates

• Filing date: May 25, 1995
• Grant date: Sep 30, 1997
• Expiry date: May 25, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H15/26
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention discloses compounds that are highly isozyme selective protein kinase C beta-1 and beta-2 isozyme inhibitors. Accordingly, the present invention provides a method of selectively inhibiting protein kinase C isozymes beta-1, and beta-2. As isozyme selective inhibitors of beta-1 and beta-2, the compounds are therapeutically useful in treating conditions associated with diabetes mellitus and its complications, as well as other disease states associated with an elevation of the beta-1 and beta-2 isozyme.