Biocompatability for solid surfaces
US5672638A · kind A · utility
68Cited by
23References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 22, 1995 |
| Grant date | Sep 30, 1997 |
| Priority date | — |
| Expiry date | Aug 22, 2015 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S623/924
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
An improved coating and spacer material for a medical device having a blood or tissue-contacting surface comprising a polyalkyleneimine layer which is crosslinked with a crosslinking agent which is at least difunctional in polymerizable vinyl groups which have adjacent strong electron-withdrawing groups and a biomolecule covalently bonded to the crosslinked polyalkyleneimine layer. For example, polyethyleneimine crosslinked with divinyl sulfone could be used. The resulting crosslinked spacer layer has improved uniformity and stability without materially limiting the covalent attachment of a biomolecule such as heparin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.