Preparation of 2',3'-didehydro-3'-deoxythymidine from 5-methyluridine
US5672698A · kind A · utility
10Cited by
1References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 23, 1994 |
| Grant date | Sep 30, 1997 |
| Priority date | — |
| Expiry date | Sep 23, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/18
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An economical process, amenable to large-scale production, is disclosed for the preparation of 2',3'-didehydro-3'-deoxythymidine (d4T) from 5-methyluridine. The process employs a novel, 5'-,acyl-2'.alpha.-halo-3'.alpha.-alkanesulfonylthymidine intermediate as well as a highly efficient and practical deprotection, isolation and purification procedure for the d4T product.
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