Bicyclooctane and bicycloheptane derivatives

US5674905A · kind A · utility

Assignee

• The James Black Foundation Limited · GB

Inventors

• Sarkis Barret Kalindjian · Banstead, GB
• Caroline Minli Rachel Low · Leatherhead, GB
• Michael John Pether · London, GB
• Jonathan Michael Richard Davies · East Kilbride, GB
• David John Dunstone · London, GB
• Iain Mair McDonald · Ashford, GB

Key dates

• Filing date: Dec 19, 1994
• Grant date: Oct 7, 1997
• Expiry date: Dec 19, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2603/88
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of formula (I), wherein A is selected from (a), (b), (c), (d), (e), (f) and B is selected from (g), (h), and (i), wherein W is a carbonyl, sulphonyl or sulphinyl group, and X is a carbonyl, sulphonyl or sulphinyl group or --C(O)--CH.sub.2 -- (in which the carbonyl group is bonded to Y), provided that at least one of W and X contains carbonyl, Y is R.sub.9 --O-- or R.sub.9 --N(R.sub.10)--, Z is selected from (i), (ii), (iii), (iv) or Z is absent and W is H, with a number of provisions and phamaceutically acceptable salts thereof are ligands at CCK and/or gastrin receptors. ##STR1##