Bioassay for thrombogenesis and rabbit model
US5675058A · kind A · utility
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Key dates
| Filing date | Sep 7, 1993 |
| Grant date | Oct 7, 1997 |
| Priority date | — |
| Expiry date | Sep 7, 2013 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/4905
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An in vivo assay for determining the potential thrombogenic activity of a test compound entails pre-treating an animal with both a hepatoxin and either a bacterial agent (whole bacteria or bacterial toxins, including endotoxins) or a bacterial agent-induced cytokine, which pre-treatment enhances sensitivity to thrombogenic substances. The sensitized animal can be used in identifying a thrombogenic substance even when it is a weak potentiator of thrombogenesis, and in detecting smaller amounts of a strong potentiator.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.