Method for sterilizing liquid chromatography resins highly resistant to oxidation and a sterilization solution for use therein
US5676837A · kind A · utility
18Cited by
10References
27Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 7, 1996 |
| Grant date | Oct 14, 1997 |
| Priority date | — |
| Expiry date | Jun 7, 2016 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N30/50
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
A method for sterilizing liquid chromatography resins that are highly resistant to oxidation by strongly oxidizing agents and a sterilization solution for use therein. In a preferred embodiment, the invention comprises contacting an oxidant-resistant chromatographic resin with an aqueous solution of peracetic acid and up to 40% ethanol. In particular, where the solution is to be used to sterilize a positively charged ion-exchange resin, the solution preferably additionally includes an acetate buffer of a sufficient ionic strength to prevent adsorption of the peracetic acid ions on the resin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.