Methods of obtaining compositions enriched for hematopoietic stem cells, compositions derived therefrom and methods of use thereof
US5677136A · kind A · utility
91Cited by
4References
26Claims
0Family size
Assignee
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Key dates
| Filing date | Nov 14, 1994 |
| Grant date | Oct 14, 1997 |
| Priority date | — |
| Expiry date | Nov 14, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2502/1394
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for obtaining human hematopoietic stem cells is provided by enrichment for stem cells using a novel stem cell marker. Compositions enriched for stem cells are obtained using novel antibody HCC-1 which is specific for a CD59 epitope highly accessible on stem cells, and less accessible or absent on mature cells. The enriched population of cells derived from these methods are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.