Use of peptide derivatives for the preparation of medicaments inhibiting endopeptidases 24.15 and 24.16
US5677281A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 9, 1993 |
| Grant date | Oct 14, 1997 |
| Priority date | — |
| Expiry date | Apr 9, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P29/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to the use of peptide derivatives for the preparation of medicaments inhibiting endopeptidases 24.15 and 24.16. These peptide derivatives are in accordance with the formula: ##STR1## in which R.sup.1 is an optionally substituted aralkyl group, R.sup.2 is Pro, Hyp, thiazolidine or dehydroproline, R.sup.3 is H or an alkyl radical, R.sup.4 is an alkyl group or the side chain of an amino acid, R.sup.5 and R.sup.6 can be H, NH.sub.4 + or metals and R.sup.7 is H or CH.sub.3. N-(phenylethylphosphonyl)-Gly-Pro-aminohexanoic acid and N-(phenylethyl phosphonyl)-Ala-Pro-aminohexanoic acid are examples of effective derivatives.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.