Benzazepine-, benzoxazepine- and benzothiazepine-n-acetic acid derivatives, process for their preparation and pharmaceutical compositions containing them

US5677297A · kind A · utility

Assignee

• Solvay Pharmaceuticals, GmbH · US

Inventors

• Harald Waldeck · Hannover, DE
• Dagmar Hoeltje · Gehrden, DE
• Josef Messinger · Sehnde, DE
• Jochen Antel · Annaberg-Buchholz, DE
• Michael Wurl · Garbsen, DE
• Dirk Thormaehlen · Gronau, DE

Key dates

• Filing date: Mar 22, 1996
• Grant date: Oct 14, 1997
• Expiry date: Mar 22, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds with neutral endopeptidase (NEP) inhibitory activity corresponding to the formula I ##STR1## in which R.sup.1 is a lower alkoxy-lower-alkyl group whose lower alkoxy radical is substituted by a lower alkoxy group, or a phenyl-lower-alkyl or phenyloxy-lower-alkyl group which can optionally be substituted in the phenyl ring by lower alkyl, lower alkoxy or halogen, or a naphthyl-lower-alkyl group, PA1 A is CH.sub.2, O or S, PA1 R.sup.2 is hydrogen or halogen, PA1 R.sup.3 is hydrogen or halogen, PA1 R.sup.4 is hydrogen or a group forming a biolabile ester, and PA1 R.sup.5 is hydrogen or a group forming a biolabile ester, and the physiologically acceptable acid addition salts thereof.