Thiadiazole compounds useful as proton pump inhibitors
US5677302A · kind A · utility
12Cited by
2References
32Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 26, 1996 |
| Grant date | Oct 14, 1997 |
| Priority date | — |
| Expiry date | Feb 26, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel thiadiazole compounds are provided, which are effective as proton pumps inhibitors, useful in treating peptic ulcers by inhibition of the proton pump enzyme H.sup.+ /K.sup.+ -ATPase. The compounds are 3-substituted 1,2,4-thiadiazolo 4,5-.alpha.!benzimidazole and 3-substituted imidazo1,2-d!-1,2,4-thiadiazoles corresponding to the general formula: ##STR1## where X and Z either represent an optionally substituted benzene ring fused to the diazole nucleus, or represent a variety of independent chemical groupings (hydrogen, lower alkyl, halo, etc.) and Y is an electronegative group.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.