Polycyclic complexing agents

US5677445A · kind A · utility

Assignee

• NYCOMED IMAGING AS · NO

Inventors

• John L. Toner · Libertyville, US
• David A. Hilborn · Henrietta, US
• Bruce J. Murray · Walworth, US
• Timothy Z. Hossain · Austin, US

Key dates

• Filing date: Dec 15, 1995
• Grant date: Oct 14, 1997
• Expiry date: Dec 15, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound of formula ##STR1## where the two R.sup.2 groups, taken together, represent the atoms necessary to complete a macrocyclic ring structure containing at least one heteroatom coordinating site and at least one alkylene group forming part of the ring structure; R.sup.3 represents hydrogen, alkyl, alkoxy, alkylthio, alkylamino, alkylformamido, aryl, aryloxy, heterocyclyl or a protein reactive group; and R.sup.4 represents hydrogen or a protein reactive group, provided that at least one of the R.sup.4 groups is a protein reactive group, and salts, complexes and protein conjugates thereof.