Matrix with immunomodulating activity
US5679354A · kind A · utility
Inventors
Key dates
| Filing date | May 21, 1991 |
| Grant date | Oct 21, 1997 |
| Priority date | — |
| Expiry date | May 21, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/55577
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention claims an iscom matrix which is not a lipid vesicle comprising at least one lipid and at least one saponim but no intentional antigenic determinants and optionally also adjuvants for use as an immunomodulating agent, medicines, vaccines, kits containing the matrix and new saponins, and a process for preparing the new saponins. The invention also concerns a process for preparing the matrix characterized in that at least one sterol is solubilized in a solvent or detergent, the saponin or saponins are added, the other adjuvants and lipids are optionally also added, whereafter the organic solvent or the detergent may be removed for example with dialysis, ultra filtration, gel filtration or electrophoresis. The sterol and saponin might also be solubilized in the lipids and/or adjuvants.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.