Mycobacterial reporter strains and uses thereof
US5679515A · kind A · utility
5Cited by
2References
38Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 3, 1994 |
| Grant date | Oct 21, 1997 |
| Priority date | — |
| Expiry date | Oct 3, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/6897
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
This invention relates to a method of quantifying bacteria in vivo or in vitro using bacterial reporter strains. In particular this invention provides a method utilizing mycobacterial reporter strains that permits rapid screening for in vivo antimycobacterial activity of various compositions. In addition this invention provides for particular mycobacterial reporter strains expressing the FFlux gene at levels sufficiently high to allow detection in tissue homogenates without lysis or concentration of the bacteria.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.