Methods of detecting .beta.A4 peptide species ending at carboxy-terminus residue 42 using monoclonal antibody 369.2B
US5679531A · kind A · utility
39Cited by
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3Claims
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Key dates
| Filing date | Jun 7, 1995 |
| Grant date | Oct 21, 1997 |
| Priority date | — |
| Expiry date | Jun 7, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/505
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The instant invention provides for monoclomal antibody 369.2B which is specific for the .beta.A4 peptide, and in particular the free C-terminus of .beta.A4 "1-42" but not "1-43", and stains diffuse and fibrillar amyloid, vascular amyloid, and neurofibrillary tangles. The instant invention further provides for antibody fragments and constructs thereof which have the same binding specificity. The instant invention also provides for methods of diagnosis, screening and therapeutics for treating unique forms of .beta.A4 peptide, using the antibodies of the instant invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.