Screening method for identifying ligands for target proteins
US5679582A · kind A · utility
71Cited by
3References
47Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 21, 1994 |
| Grant date | Oct 21, 1997 |
| Priority date | — |
| Expiry date | Jun 21, 2014 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/94
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A novel method for screening chemical compounds, test ligands, for potential pharmaceutical effectiveness. The disclosed method identifies possible therapeutic test ligands by placing them in the presence of target proteins and determining the ability of test ligands to increase the ratio of folded target protein to unfolded target protein. This differs significantly from known methods of novel pharmaceutical testing in that the biochemical function of the target protein need not be known and, except for one of the five embodiments of the method, the existence of any known ligands of the target protein is unnecessary.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.