Monoclonal antibodies for the selective immunological determination of intact procollagen peptide (type III) and procollagen (type III) in body fluids

US5679583A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Dietrich Brocks · Wiesbaden, DE
• Jurgen Punter · Hofheim, DE
• Helmut Strecker · Seeheim-Jugenheim, DE
• Rupert Timpl · Gauting, DE
• Volkmar Gunzler-Pukall · Marburg, DE
• Henning Hachmann · Frankfurt am Main, DE

Key dates

• Filing date: Apr 5, 1995
• Grant date: Oct 21, 1997
• Expiry date: Apr 5, 2015

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/6878
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

It is possible with the aid of a monoclonal antibody which is specifically directed against an epitope of amino-terminal procollagen peptide (type III) which is not present on the fragment Col 1, and of a second monoclonal or polyclonal antibody against an epitope of amino-terminal procollagen peptide (type III), to determine said peptide with great accuracy. It is also, possible, with the aid of a monoclonal antibody which is specifically directed against an epitope of amino-terminal procollagen peptide (type III) which is not present in Col 1, to determine with great accuracy said procollagen peptide in body fluids.