Glutathione analogs and paralog panels comprising glutathione mimics
US5679643A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 31, 1994 |
| Grant date | Oct 21, 1997 |
| Priority date | — |
| Expiry date | May 31, 2014 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N30/02
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Compounds of the formula: ##STR1## or a salt thereof, wherein n is 1 or 2; wherein when n is 1, X is a mono- or disubstituted or unsubstituted C.sub.1-20 hydrocarbon radical wherein any substitution is selected from the group consisting of halo, OR, and SR, wherein R is H or C.sub.1-4 alkyl; and wherein, when n is 2, one X is defined as for n=1 and the other X is lower C.sub.1-4 alkyl; ##STR2## wherein m is 1 or 2; AA.sub.C is an amino acid coupled through a peptide bond to the remainder of the compound of Formula (1) selected from the group consisting of glycine, valine, alanine, 4-aminobutyric acid, aspartic acid, phenylglycine, histidine, tryptophan, tyrosine, and phenylalanine, wherein the phenyl group of phenylalanine or phenylglycine may optionally contain a single substitution selected from the group consisting of halo, OR, and SR, wherein R is H or C.sub.1-4 alkyl; with the proviso that if Y is ##STR3## AA.sub.C is not Gly; and if Y is ##STR4## and X is benzyl, AA.sub.C cannot be Val are useful as affinity ligands and as diagnostic reagents. These compounds and analogous tripeptide glutathione analogs can be used as members of panels to obtain specific characteristic profil…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.