Solvent for a sparingly soluble gentamicin salt

US5679646A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Monika Cimbollek · Mannheim, DE
• Berthold Nies · Kassel, DE

Key dates

• Filing date: May 4, 1994
• Grant date: Oct 21, 1997
• Expiry date: May 4, 2014

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2300/406
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A solvent for the salt of gentamicin with 3-p-methoxybenzylidene-6-hydroxy-4 '-methoxyflavanone-6-phosphate which is a mixture of from 6 to 9.75 parts by volume of tetrahydrofuran and from 4 to 0.25 parts by volume of water. In these solvents the active compound is soluble up to about 60% by weight. Such a solution is particularly suitable for loading pharmaceutical carriers with this active compound.