Hydroxyalkylammonium-pyrimidines and nucleoside derivatives, useful as inhibitors of inflammatory cytokines

US5679684A · kind A · utility

Assignees

• Macronex, Inc. · US
• The University of N.C. at Chapel Hill · US

Inventors

• Bradley J. Benson · Chapel Hill, US
• Xiannong Chen · Athens, US
• George J. Cianciolo · Durham, US
• Jose-Luis Diaz · San Jose, US
• Khalid S. Ishaq · Chapel Hill, US
• Susan L. Morris-Natschke · Apex, US
• Ronald J. Uhing · Durham, US
• Henry Wong · Candiac, CA

Key dates

• Filing date: Jun 7, 1995
• Grant date: Oct 21, 1997
• Expiry date: Jun 7, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/16
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel hydroxyalkylammonium-pyrimidine of the formula ##STR1## and nucleoside derivatives have been found to be useful as inhibitors of inflammatory cytokines. They can be used, inter alia, in the therapy of septic shock, cachexia, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis and AIDS. The compounds are typically prepared by reaction of an iodo substituted nucleoside with the appropriately substituted hydroxyalkylamine.