Molecule labelling using 2-hydraninopyridine derivatives

US5679778A · kind A · utility

Assignee

• Johnson Matthey Public Limited Company · GB

Inventors

• Michael J. Abrams · Glenmoore, US
• Gary Bridger · Bellingham, US
• David A. Schwartz · Encinitas, US
• Sreenivasan Padmanabhan · Exton, US
• Michael E. Ultee · Montgomery, US

Key dates

• Filing date: Jun 30, 1995
• Grant date: Oct 21, 1997
• Expiry date: Jun 30, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A compound of formula I ##STR1## in which E is an alkenyl group or represents H.sub.2 in which case the compound is in acid addition salt form, J is selected from --CO--NH--, --CO--O--, --CO--S-- and --NH--CO--, T is an alkylene chain, or, if J is --CO--NH--, T is the residue of an amino acid moiety, Q is a hydrophilic or cleavable moiety, and Z is an amine- and/or thiol-reactive moiety. Conjugates formed by reacting such compound with a macromolecule, e.g. an immunoglobulin, and labelled macromolecules comprising a metal atom bound to such conjugate are also disclosed.