Tetronic and thiotetronic acid derivatives as phospholipase A.sub.2 inhibitors
US5679801A · kind A · utility
3Cited by
0References
19Claims
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Assignee
Inventors
Key dates
| Filing date | May 15, 1995 |
| Grant date | Oct 21, 1997 |
| Priority date | — |
| Expiry date | May 15, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D333/32
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
There are disclosed compounds of the formula: ##STR1## wherein X is --CH.sub.2 R; PA1 Y is --O-- or --S--; PA1 R.sup.1 and R.sup.2 are each, independently, hydrogen or lower alkyl; PA1 or a pharmaceutically acceptable salt thereof; which by virtue of their ability to inhibit PLA.sub.2, are of use as antiinflammatory agents and there is also disclosed a method for the treatment of immunoinflammatory conditions, such as allergy, anaphylaxis, asthma and inflammation in mammals.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.