Preparation of taxol and docetaxel through primary amines
US5679807A · kind A · utility
9Cited by
5References
27Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 30, 1995 |
| Grant date | Oct 21, 1997 |
| Priority date | — |
| Expiry date | Jan 30, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D305/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to a process for converting Taxol A, B and C to Taxol primary amine which can then be easily and efficiently converted to Taxol A or docetaxel, thereby significantly increasing the yield of these products from biomass. The method includes the removal of the amide from the side-chain with Schwartz's reagent to form an imine, followed by the hydrolysis of the imine to the primary amine. The primary amine can then be converted to Taxol A or docetaxel. New Taxol imine compounds and primary amine salts have been formed by this process.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.