Betulinic acid and dihydrobetulinic acid derivatives and uses therefor
US5679828A · kind A · utility
41Cited by
1References
12Claims
0Family size
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Inventors
Key dates
| Filing date | Jun 5, 1995 |
| Grant date | Oct 21, 1997 |
| Priority date | — |
| Expiry date | Jun 5, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2603/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Some betulinic acid and dihydrobetulinic acid acyl derivatives according to the present invention have been found to have potent anti-HIV activity. Introducing a C.sub.2 -C.sub.20 substituted or unsubstituted acyl group at the C.sub.3 -hydroxy group of betulinic acid and dihydrobetulinic acid produces the corresponding 3-O-acyl derivatives. The compounds of the present invention have the following formulae: ##STR1## where R may be a mono- or dicarboxylacyl group, substituted or unsubstituted, of from about 2 to about 20 carbon atoms, and R' may be hydrogen or a C.sub.2 -C.sub.10 substituted and unsubstituted alkyl or aryl group.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.