Bifunctional urokinase variants with improved fibrinolytic characteristics and thrombin inhibiting effect

US5681721A · kind A · utility

Assignee

• Gruenenthal GmbH · DE

Inventors

• Gerd J. Steffens · Aachen, DE
• Stephan Wnendt · Aachen, DE
• Johannes Schneider · Stolberg, DE
• Regina Heinzel-Wieland · Darmstadt, DE
• Derek Saunders · Aachen, DE

Key dates

• Filing date: Jul 20, 1993
• Grant date: Oct 28, 1997
• Expiry date: Jul 20, 2013

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Bifunctional urokinase variants possessing improved fibrinolytic properties and thrombin inhibitory activities, plasmids used in the production of these polypeptides, as well as thrombolytic agents containing one of the bifunctional urokinase variants as active ingredient are described.