Class of phosphocholine derivatives having antifungal activity

US5681829A · kind A · utility

Assignee

• Shaman Pharmaceuticals, Inc. · US

Inventors

• Michael S. Tempesta · Moss Beach, US
• Shivanand D. Jolad · Tucson, US
• Steven Row King · Moss Beach, US
• Guohua Mao · Redwood City, US
• Reimar Bruening · Redwood City, US
• John E. Kuo · Mountain View, US
• Thien V. Troung · Emeryville, US
• Donald Bierer · Daly City, US
• Jeffrey Mark Dener · Menlo Park, US

Key dates

• Filing date: Apr 5, 1995
• Grant date: Oct 28, 1997
• Expiry date: Apr 5, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H15/18
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Certain phosphocholine derivatives having substantial antifungal therapeutic activity are disclosed. The phosphocholine derivatives may be chemically synthesized, enzymatically prepared or extracted from the plant Irlbachia alata. The phosphocholine derivatives are useful in treating fungal infections including those which are dermatophytic, systemic, ophthalmic and vaginal.