Patent · US Expired

Sugar modified nucleosides and oligonucleotides

US5681940A · kind A · utility

102Cited by

1References

9Claims

0Family size

Assignee

ICN Pharmaceuticals, Inc. · US

Inventors

Guangyi Wang · Carlsbad, US
Kandasamy Ramasamy · Laguna Hills, US
Wilfried Seifert · Village of La Jolla, US

Key dates

Filing date	Nov 2, 1994
Grant date	Oct 28, 1997
Priority date	—
Expiry date	Nov 2, 2014

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07H21/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A number of modified nucleosides are disclosed composed of modified sugar moieties which contain substituents at C1 and C4 positions, or branched substituents at C3 and C5 positions of deoxyribose or ribose. Each nucleoside is converted to or properly protected and then converted to the corresponding phosphoramidites. These phosphoramidites are used to assemble oligonucleotides in which there is at least one forenoted nucleosides. These sugar modified oligonucleotides have the potential to be used as antisense therapies since they are expected to enhance nuclease resistance and cellular uptake while they maintain sequence-specificity and affinity to nucleic acid targets in vitro or in vivo.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.