Permeable, non-irritating prodrugs of nonsteroidal and steroidal agents
US5681964A · kind A · utility
43Cited by
11References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 5, 1994 |
| Grant date | Oct 28, 1997 |
| Priority date | — |
| Expiry date | Oct 5, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J51/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Prodrugs containing an active drug molecule linked to a polyethylene glycol group, and a method of use thereof are described. Exemplary soluble ester prodrugs contain naproxen, triamcinolone acetonide, gancyclovir, taxol, cyclosporin, dideoxyinosine, trihydroxy steroids, and flurbiprofen molecules linked to polyethylene glycol (PEG) groups. Pharmaceutical compositions containing these prodrugs, and a method of using these esters for treating disease states or symptoms are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.