Method for the preparation of .beta.-phenylisoserine derivatives
US5681970A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 28, 1995 |
| Grant date | Oct 28, 1997 |
| Priority date | — |
| Expiry date | Sep 28, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C233/87
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Method for the preparation of .beta.-phenylisoserine derivatives of general formula (I) involving the action of an anhydride and hydrogen with a product of general formula (II). The products of general formula (I) are especially useful in the preparation of taxoids having outstanding antitumour properties. In general formulae (I) and (II), Ar is an aryl radical, Ph is a phenyl radical or an optionally substituted .alpha. or .beta.-naphtyl, R is a hydrogen atom or an alkyl radical optionally substituted by a phenyl radical and R.sub.1 is an optionally substituted phenyl radical or a R.sub.2 --O radical wherein R.sub.2 is an alkyl, alkenyl, cycloalkyl, phenyl or heterocyclyl. ##STR1##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.