EGS-mediated inactivation of target RNA

US5683873A · kind A · utility

Assignee

• Innovir Laboratories, Inc. · US

Inventors

• Shaji T. George · New York, US
• Michael Ma · Mississauga, CA
• Martina Werner · Aliso Viejo, US
• Umberto Pace · Yonkers, US
• Allan R. Goldberg · New York, US

Key dates

• Filing date: Jan 13, 1995
• Grant date: Nov 4, 1997
• Expiry date: Jan 13, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2799/028
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Modified external guide sequence (EGS) molecules that mediate cleavage of specific target RNAs have been constructed. The modified molecules are external guide sequence molecules for RNAse P which are designed to specifically bind to and promote RNAse P-mediated cleavage of target RNA molecules and to have enhanced nuclease resistance. Specific regions are modified to achieve enhanced stability while maintaining RNAse P activity. Modified external guide sequence molecules suitable for use in the treatment of hepatitis B viral infections have been constructed.