Dihydorbenzofuran and related compounds useful as anti-inflammatory agents
US5684002A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 7, 1995 |
| Grant date | Nov 4, 1997 |
| Priority date | — |
| Expiry date | Jun 7, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D333/54
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A compound having the structure: ##STR1## wherein (a) W is --C(X')--NRR' or --NR--C(X')R'; PA1 (b) X and X' are independently O or S; PA1 (c) each Y is independently hydrogen or straight, branched or cyclic alkanyl having from 1 to about 3 carbon atoms, or the two Y's are bonded to form an alkanyl ring having from 3 to about 7 carbon atoms; PA1 (d) Z is unsubstituted branched or cyclic alkyl, or unsubstituted or alkanyl-substituted phenyl or benzyl, Z having from 3 to about 10 atoms other than hydrogen; PA1 (e) R and R' are each independently selected from hydrogen, hydroxy straight, branched or substituted alkyl having from 1 to about 6 carbon atoms, and cyclic alkyl having from 3 to about 7 carbon atoms; unsubstituted or substituted aryl, heteroaryl or heterocyclic groups; or R and R' are bonded together to form a ring having from from 3 to about 8 atoms wherein about 1 to about 4 atoms may be heteroatoms; pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.