1-arylsulphonyl, arylcarbonyl and 1-arylphosphonyl-3-phenyl-1,4,5,6-tetrahydropyridazines
US5684151A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Mar 6, 1995 |
| Grant date | Nov 4, 1997 |
| Priority date | — |
| Expiry date | Mar 6, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/650905
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed are progestin agonists having the following formula: ##STR1## W is absent or --CH.dbd.CH--; R.sup.1 are independently selected from the group consisting of halogen, --CF.sub.3, and NO.sub.2, or both R.sup.1 may be joined to form a bi-radical which is --CH.dbd.CHCH.dbd.CH--; PA0 R.sup.3 are independently selected from the group consisting of hydrogen, C.sub.1-6 branched or linear alkyl, halogen and --CF.sub.3, with the proviso that R.sup.3 at the 3-position must be H where R.sup.3 at the 4-position is H, or both R.sup.3 may be joined to form a bi-radical selected from the group consisting of --CH.dbd.CHCH.dbd.CH--, --C(NC.sub.1-4 alkyl.sub.2)=CHCH.dbd.CH-- and --(CH.sub.2).sub.4 --; PA0 R.sup.5 is selected from the group consisting of H and Me; with the proviso that only one of R.sup.1 and R.sup.3 forms the fused bi-radical; and the stereoisomers.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.