Preparation of carboxyalkyl derivatives as inhibitors of matrix metalloproteinases
US5684152A · kind A · utility
3Cited by
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10Claims
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Key dates
| Filing date | Sep 19, 1996 |
| Grant date | Nov 4, 1997 |
| Priority date | — |
| Expiry date | Sep 19, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C237/22
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Carboxy-peptidyl compounds of Formula I are found to be useful inhibitors of matrix metalloendoproteinase-mediated diseases including osteoarthritis, rheumatoid arthritis, septic arthritis, tumor invasion in certain cancers, periodontal disease, corneal ulceration, proteinuria, dystrophobic epidermolysis bullosa, coronary thrombosis associated with atherosclerotic plaque rupture, and aneurysmal aortic disease. This invention relates to a process of making the carboxy-peptidyl compounds of formula I. ##STR1##
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