Microcapsules of predetermined peptide(s) specificity (ies), their preparation and uses

US5686113A · kind A · utility

Assignee

• Temple University-Of The Commonwealth System of Higher Education · US

Inventors

• Tully J. Speaker · Philadelphia, US
• Kenneth Sultzbaugh · Bound Brook, US

Key dates

• Filing date: Mar 21, 1995
• Grant date: Nov 11, 1997
• Expiry date: Mar 21, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/5073
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An aqueous core microcapsule has a capsular wall provided with a peptide(s) of pre-determined binding specificity(ies) appended to the surface, the wall being the reaction product of an anionic polymer or salt thereof and a polyamine, salt thereof, mixtures thereof, or mixtures thereof with monoamines. The aqueous core may contain an active ingredient(s), and be targeted for delivery to specific cell tissues. The microcapsules are provided as a composition and in a kit with instructions for use in imaging, diagnosis, therapy, vaccination, and other applications.