3,3-diphenylpropylamines, their use and preparation

US5686464A · kind A · utility

Assignee

• Pharmacia AB · SE

Inventors

• Rolf Johansson · Huddinge, SE
• Pinchas Moses · Boo, SE
• Lisbeth Nilvebrant · Bromma, SE
• Bengt Sparf

Key dates

• Filing date: Jul 22, 1996
• Grant date: Nov 11, 1997
• Expiry date: Jul 22, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C215/54
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A 3,3-diphenylpropylamine of the formula I, or its physiologically acceptable acid salt thereof: ##STR1## wherein R.sup.1 represents hydrogen or methyl, R.sup.2 and R.sup.3 independently represent hydrogen, methyl, methoxy, hydroxy, carbamoyl, sulphamoyl or halogen, and X represents a tertiary amino group of formula II ##STR2## wherein R.sup.4 and R.sup.5 independently represent a hydroxy substituted or unsubstituted non-aromatic hydrocarbyl group which can join together to form a ring and which together contain at least three carbon atoms, wherein at least one of R.sup.4 and R.sup.5 is hydroxy substituted, is useful in treating acetylcholine-mediated disorders such as urinary incontinence.