Domains of extracellular region of human platelet derived growth factor receptor polypeptides

US5686572A · kind A · utility

Assignees

• COR Therapeutics, Inc. · US
• The Regents of the University of California · US

Inventors

• David L. Wolf · Palo Alto, US
• James E. Tomlinson · Horsham, GB
• Larry J. Fretto · Palo Alto, US
• Neill A. Giese · San Francisco, US
• Jaime Escobedo · San Francisco, US
• Lewis T. Williams · San Francisco, US

Key dates

• Filing date: Dec 15, 1993
• Grant date: Nov 11, 1997
• Expiry date: Dec 15, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Defined constructs of modified human platelet-derived growth factor receptor polypeptides are provided. Extracellular region domain structures are identified and modifications and combinatorial rearrangements of the receptor segments are provided. Both cell bound and soluble forms of modified segments are made available, as are methods for assays using them, allowing for screening of ligand analogues.