Patent · US Expired

Methods and compositions for inhibiting thrombogenesis

US5688507A · kind A · utility

5Cited by
6References
4Claims
0Family size

Assignee

Inventors

Key dates

Filing dateNov 13, 1995
Grant dateNov 18, 1997
Priority date—
Expiry dateNov 13, 2015

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12Y304/21005
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Thrombus or clot formation and accretion are inhibited by administering thrombin-displacing substances to a patient. The thrombin-displacing substances comprise either thrombin analogs which bind to the thrombin-binding site on fibrin or fibrin analogs which bind to a fibrin-binding site on thrombin. By displacing the thrombin from clot or thrombus, the thrombin is released into circulation where it is inactivated by endogenous anti-proteinases. The fibrin analogs which bind to the fibrin-binding site on thrombin may be linked to a second binding moiety which binds to and/or inactivates the catalytic site on thrombin to further inhibit thrombosis.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.