Non-glycopeptide antimicrobial agents in combination with an anticoagulant, an antithrombotic or a chelating agent, and their uses in, for example, the preparation of medical devices
US5688516A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Oct 3, 1994 |
| Grant date | Nov 18, 1997 |
| Priority date | — |
| Expiry date | Oct 3, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61M2025/0056
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Compositions and methods of employing compositions in flushing and coating medical devices are disclosed. The compositions include selected combinations of a chelating agent, anticoagulant, or antithrombotic agent, with an non-glycopeptide antimicrobial agent, such as the tetracycline antibiotics. Methods of using these compositions for coating a medical device and for inhibiting catheter infection are also disclosed. Particular combinations of the claimed combinations include minocycline or other non-glycopeptide antimicrobial agent together with EDTA, EGTA, DTPA, TTH, heparin and/or hirudin in a pharmaceutically acceptable diluent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.