Method for assessing sensitivity of tumor cells to cephalomannine and 10-deacetyltaxol
US5688517A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 29, 1993 |
| Grant date | Nov 18, 1997 |
| Priority date | — |
| Expiry date | Jan 29, 2013 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/815
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method for assessing the sensitivity of a patient's tumor cells to cephalomannine and 10-deacetyltaxol in order to treat those tumor cells involves the removal of a sample of the tumor cells and establishing a cell line therefrom. Cells from the cell line are cultured and then contacted with varying concentrations of cephalomannine or 10-deacetyltaxol to form treated cells. The treated cells are assessed to determine the cytotoxic effect of the cephalomannine and/or the 10-deacetyltaxol and, where cytotoxic response is exhibited, a therapeutic dosage is formulated using the selected concentration of cephalomannine or 10-deacetyltaxol and a carrier material. The method is particularly useful for neural and glial tumor cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.