Prevention of protein aggregation
US5688651A · kind A · utility
122Cited by
1References
4Claims
0Family size
Assignee
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Key dates
| Filing date | Dec 16, 1994 |
| Grant date | Nov 18, 1997 |
| Priority date | — |
| Expiry date | Dec 16, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K48/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of selecting anti-aggregation molecules with chaperone-like activity that have characteristics including binding to a native target molecule epitope with a high binding constant and are non-inhibitory to the biological activity of the target molecule. The method molecules denaturating a target molecule in the presence of presumptative antiaggregation molecules to prevent the target molecules from self-or induced-aggregation. The nonaggregated target molecule coupled to the anti-aggregation molecule is then tested for bioactivity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.